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Before we delve deeper, let me give you a bit of background.When people suffer from bipolar disorder, also known as manic-depressive illness, their mood swings between two extremes: mania and depression.That means you may go for months—or even years—feeling like you’re constantly being thrown for a loop by everyone else’s whims. If leaders don’t set clear boundaries on when they will and won’t be available to answer constituents’ and colleagues’ questions, they never feel like they have a break.Most constituents don’t know what’s reasonable in your position, so for everyone to be happy you need to let them know what to expect. What do you suggest to set time expectations about email, voicemail, etc.?Fred Tatasciore, 377 other games Steven Jay Blum, 336 other games Jennifer Hale, 206 other games Scott Johnson, 194 other games Troy Baker, 154 other games Grey De Lisle, 154 other games Jon Broadbridge, 145 other games Scott Ritchie, 141 other games Tara Strong, 130 other games Remi Sklar, 126 other games Martin Tremblay, 121 other games Debra Baker, 118 other games Samantha Ryan, 108 other games Ronald Dutch Hill, 107 other games Philippe Juton, 106 other games Patrick Seitz, 105 other games Jennifer Stump, 105 other games Richard Epcar, 102 other games Peter Wyse, 99 other games Wendy Bozzi, 98 other games Steve Chalk, 98 other games Jane Elms, 95 other games Phil La Marr, 95 other games Gary Lake-Schaal, 95 other games Kevin Kebodeaux, 94 other games Mortal Kombat X, a group of 513 people Injustice: Gods Among Us - Ultimate Edition, a group of 324 people Injustice: Gods Among Us, a group of 305 people WWE Immortals, a group of 234 people Batman: Arkham Knight, a group of 198 people Middle-earth: Shadow of Mordor, a group of 198 people Mad Max, a group of 196 people Mortal Kombat, a group of 157 people Batman: Arkham Origins, a group of 122 people Batman: Arkham Origins - Cold, Cold Heart, a group of 118 people Infinite Crisis, a group of 118 people Batman: Arkham Underworld, a group of 111 people Dying Light: Enhanced Edition, a group of 108 people Batman: Arkham VR, a group of 96 people Mortal Kombat vs.When you and your stakeholders don’t see eye-to-eye on the timing of communications and deadlines—stress happens. The challenge for leaders is that if you don’t set expectations, your stakeholders will.Are there any other ways leaders can eliminate deadline stress?

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To find out, the Baylor team created a strain of genetically engineered mice that produces 50% more Shank3 protein than normal mice.

Now, an NIH-funded team at Baylor College of Medicine has demonstrated for the first time that extra copies of a gene that codes for a protein called Shank3 can cause manic episodes similar to those seen in some types of bipolar disorder.

The researchers initially tested their hypothesis in mice and then, building upon those findings, went on to find extra copies of the gene in two human patients—one with seizures and attention deficit hyperactivity disorder and another with seizures and bipolar disorder.

The researchers then explored how extra amounts of Shank3 protein wreak havoc inside the brain.

In lab studies that examined brain cells, called neurons, derived from the Shank3 mice, the researchers found that higher-than-normal levels of Shank3 boosted the number of dendritic spines on the neurons.

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